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Alpha-1 antitrypsin deficiency6: new and emerging treatments for alpha-1 antitrypsin deficiency

10.1371/journal.pone.0066418 58

doi: 10.1016/j.taap.2015.06.017 177 SunYLiL

19 It was found that MPTP can freely cross the bloodbrain barrier, is selectively taken up by dopaminergic cells, and inhibits mitochondrial complex 1 function in the respiratory chain, an established factor in the PD pathophysiology